منابع مشابه
PGC-1α Turbocharging mitochondria
dinated with the neuronal differentiation program through the InR/TOR pathways? Cell growth is potently affected by the levels of InR or TOR activation in the ommatidial clusters, but growth per se cannot account for changes in the timing of differentiation, since induction of other growth regulators like dMyc or CyclinD/Cdk4 has no effect on the tempo of ommatidial differentiation. The InR and...
متن کاملPGC−1α Promoter Methylation in Parkinson’s Disease
The etiopathogenesis of sporadic Parkinson's disease (PD) remains elusive although mitochondrial dysfunction has long been implicated. Recent evidence revealed reduced expression of peroxisome proliferator-activated receptor gamma coactivator-1 α (PGC-1α) and downstream regulated nuclear encoded respiratory complex genes in affected brain tissue from PD patients. We sought to determine whether ...
متن کاملRole of PGC-1α in Vascular Regulation
The Vascular Endothelium Endothelial cells form a continuous single-layer sheet (endothelium) lining the inside of blood vessels. The endothelium is essential in modulating vascular tone, in part, by production of vasoactive substances that act on surrounding smooth muscle cells to constrict or dilate vessels. In healthy human vessels exposed to physiological laminar flow, nitric oxide (NO) is ...
متن کاملPGC-1α: Important for exercise performance?
Since the identification of the transcriptional co-activator peroxisome proliferator activated receptor y co-activator (PGC)-1α as a factor interacting with PPARy in brown adipose tissue (BAT) (12), it has become clear that PGC-1α plays important roles in regulating several cellular processes in many different tissues (10) including mitochondrial biogenesis in skeletal muscle (1; 9) Previously,...
متن کاملPGC-1α Induction in Pulmonary Arterial Hypertension
Idiopathic Pulmonary arterial hypertension (IPAH) is characterized by the obstructive remodelling of pulmonary arteries, and a progressive elevation in pulmonary arterial pressure (PAP) with subsequent right-sided heart failure and dead. Hypoxia induces the expression of peroxisome proliferator activated receptor γ coactivator-1α (PGC-1α) which regulates oxidative metabolism and mitochondrial b...
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ژورنال
عنوان ژورنال: Cell
سال: 2004
ISSN: 0092-8674
DOI: 10.1016/j.cell.2004.09.016